A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair
نویسندگان
چکیده
منابع مشابه
CRISPR-Cas: an adaptive immunity system in prokaryotes
Most of the archaea and numerous bacteria possess an elaborate system of adaptive immunity to mobile genetic elements known as the CRISPR (clustered regularly interspaced short palindromic repeats)-associated system (CRISPR-Cas), which consists of arrays of short repeats interspersed with unique DNA spacers and adjacent operons encompassing CRISPR-associated (cas) genes with predicted and, in s...
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CRISPR-Cas system provides the adaptive immunity against invading genetic elements in prokaryotes. Recently, we demonstrated that Csa3a regulator mediates spacer acquisition in Sulfolobus islandicus by activating the expression of Type I-A adaptation cas genes. However, links between the activation of spacer adaptation and CRISPR transcription/processing, and the requirement for DNA repair gene...
متن کاملThe CRISPR/Cas System
The epigenome is a heritable layer of information not encoded in the DNA sequence of the genome, but in chemical modifications of DNA or histones. These chemical modifications, together with transcription factors, operate as spatiotemporal regulators of genome activity. Dissecting epigenome function requires controlled site-specific alteration of epigenetic information. Such control can be obta...
متن کاملCRISPR-Cas Immunity against Phages: Its Effects on the Evolution and Survival of Bacterial Pathogens
Clustered regularly interspaced short palindromic repeats (CRISPR) loci are arrays of short repeats separated by equally short ‘‘spacer’’ sequences [1–3]. Along with the CRISPRassociated (cas) genes, they encode an adaptive immune system of archaea and bacteria that protects the cell against viral infection [4]. Remarkably, this system is capable of inserting a short piece of an infecting viral...
متن کاملCRISPR-Cas: the effective immune systems in the prokaryotes
Approximately all sequenced archaeal and half of eubacterial genomes have some sort of adaptive immune system, which enables them to target and cleave invading foreign genetic elements by an RNAi-like pathway. CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR-associated proteins) systems consist of the CRISPR loci with multiple copies of a short repeat sequence separa...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2010
ISSN: 0950-382X
DOI: 10.1111/j.1365-2958.2010.07465.x